If the format stays the same, I think you can not add too much. More monsters and items would always improve any game. :p
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Oh I'm not sure about that. Look at board games like Talisman with all expansions added, it becomes close to unplayable and very intimidating to look at. Maybe depending on HOW you add things makes a huge difference. Even if I have very powerful monsters appear on the first turn, I can control the chances of that happening and make them low. Point is, I'm afraid of bloating and confusing the player too much.