Safari is evil, don't use Safari. Tried downloading your game, but it doesn't meet the security guidelines, so can't play
Unfortunately, Google still hasn’t updated Chrome to use Metal for shaders. You can work around it, if you start Chrome from the terminal (command line):
/Applications/Google\ Chrome.app/Contents/MacOS/Google\ Chrome --use-angle=metal
This way, the game shall work from itch!
PS: Please first quit Chrome before starting it from command line.