I used a Windows PC to test the plugin, but I used a BlueTooth connection to connect the controllers to the computer. With this method, it was possible to use the controllers in an RPG Maker Game. The controllers I used, were the Nintendo Switch Joy-Cons. If you have a controller with the capability to use BlueTooth, it could work with a mac.
I personally don't own a mac, so I won't know, if this is the correct solution, but nevertheless I hope, I could help you a little bit.