Depends on what you count as "major" story. There's the reappearance of Chastity, the mystery of what happened to Emma (more scenes on that in next week's update), a surprising revelation with Lily, more lore/information on MC's mom and her past, plus the Eldritch are making their move.
Also in the immediate future: a strange new girl makes an appearance, the college is opened back up, and MC discovers something very unsettling when trying to cross a bridge!