Aaah, I'm sorry, I really don't know anymore. :( If even the Ren'Py thing doesn't work, you can try uninstalling it then reinstalling it again, maybe? Looking at your other comments though, perhaps there's something out of place with your os update? There are some games I couldn't open after updating to Sierra too, but these two tricks above have never failed me. :( Aside from them, I really have no other workarounds. I'm so sorry!