Your game came up on the thread so I gave it another try.
A very annoying bug I found is that getting hit by the neurotoxin-causing exploding enemies will give you infinite neurotoxin DoT.
I made it all the way through floor 2 while having to constantly heal and it got removed by the loading screen, but I got it in the very next room and died shortly after.
It seems to become infinite as soon as you get affected but getting affected again will increase intensity because in second floor was only a -4 DoT while on the third I got a -8 DoT
If it weren't for this bug I feel like I was getting the hang of combat, but I still think having to choose 6 different charges is too much, you could probably simplify it down to 3 charges and double the effect of each charge for example, it'd be more or less the same but with less clicking.
Another bug I found is that if you don't have the essence for your selected elements and manually remove charges by right clicking the cursor won't change to the normal one until you fire.
On that note, I suggest that, if the player doesn't have the required elements to infuse his attack, he should still be able to do a normal attack. As is, if the player wants to maintain a constant rate of fire he needs to dump all elements for just two revolver shot and then re-select them.
Either that or a "select previous combination" button would be a nice quality of life thing.
Bottom line is that it got more fun with some practice so I don't think you need to necessarily make it easier, but it could use some streamlining and maybe just an easier first floor so that people aren't one-shot immediately by the exploding guys.