As I played it and got better at it, I enjoyed it more and more.
After many, many, many attempts, I succeeded at completing it at Medium difficulty.
I did not use the electricity mix, since it would be unlikely that a player without developer hints would have been able to figure the electricity mix out. I very, very heavily abused time slowdown.
When doing alchemical mixes, I could not always decrease one component by using right-click.
A couple of times, I got trapped in rooms with no apparent enemies and red laser gates blocking the exists, basically ending runs and forcing me to commit suicide. I could hear exploding enemy ticking, but I could not figure out where the enemy was. I tried using the scythe all around the walls, and also tried using plasma-3 as an attempt at area-of-effect damage near the walls, but never figured out where the enemy might be (if it was somewhere). It would be good if you could figure out how to fix that specific instance, but if you could make the room handling have a mitigation or fallback for that kind of bug in case other similar bugs are present or occur (without making that mitigation or fallback vulnerable to exploitation by players or introducing new bugs), it would not be bad either. Like giving the gates 100,000 health, which decreases over time to 0 after 10 minutes, longer for boss rooms or rooms mean to last a long time? Unless players can use that to cheese their way through rooms in some cases.
The physics are messy, which adds to the chaos, but can also mean that an exploding enemy can be shot straight at you faster than their regular charge and explode in your face, even when you try to use freeze mixture (you can alleviate that by killing enemies quickly and destroying exploding barrels to start with). Would it be a bad change to make exploding enemies immune to physics? Or make them "heavier" against outside forces, or something?
I think there will always be "unfair" deaths in this game, but the runs are fairly quick, and the chaos and difficulty and extremely quick pace makes it feel alright after getting used to it. And there are actions the player can take to alleviate and decrease the frequency of deaths.
All in all a very nice game.
I do not know how I did it, but in one run, I somehow got two instances of the player character (maybe double-clicking the "start" button?). I ended up scything myself to death at the start of that run.