Thank you for reporting these! We're looking at getting a fix in the coming days so it stops hindering your amazing runs.
For a fix, might I suggest that the knowledge is power ability doubles the experience gain STAT instead of the experience orbs on screen for a few seconds?
This way the game doesn't have to spend resources trying to render so many particle effects and can just double a number somewhere in the backend.
That is assuming the error isn't just caused by an integer overflow.