It make sense that (100n + y)² is easier to calculate, what with less overlapping additions.
Right, but that requires memorizing squares up to at least 50, which I think is more unreasonable for most people. That's why I explained it with the 50n. I strictly used the 50n for quite a while except for numbers near between 410 & 590 or 910 and higher. From high school until I was almost 30, I only ever tried this up to about 600² and for numbers around 1000², except for rare occasions. It was only then that I realized expanding to 4-digit, 5-digit, and larger numbers was quite feasible.
> Double the 3 is 6 Multiply 6 by 33 = 198.
Would it be easier to double 33 and then multiply by 3?
You can. In my case, I automatically double the first term before really thinking about what the y is. I see that my first term is going to be 300 or 350 and instantly know that means we're going up by 600s or 700s. There may be exceptions to this if the y-term ends in 5, but normally it's an automatic step that I don't even think about.
It happens. Today (10/18) I had the misfortune of guessing 253 as my 2nd choice, when I should've gone for an even number (because since 253 gives me the same clue again, I can only narrow it down to (171, 120, 89, 48, 7)); guessing 294 gives (171, 89, 7), which is much more likely to guess correctly and get a 3-win (and also with 294 I can eliminate 171 since it and 294 are divisible by 3).
With the largest prime divisor of 41 clue, there are 12 candidates below 499. I eliminated the 458 because of the likelihood of it giving "(499-x) is a prime number" clue and I chose the median of the remaining 11 candidates, 212, which is divisible by 4. Like you, I received the same "largest prime factor is 41" clue again. However, that allowed me to eliminate more candidates because your smallest factor was 11.
212 was 499 - (7 * 41). Since it didn't give me the "x and 212's largest divisor is 2 or 4" clue, that left 171, 089, and 007. I would lean against 171 because I didn't have "(212-x) is a prime number" and for lack of anything else, I chose the middle one of the three to guarantee I'd get it in 3 or 4.
As for the guesses that were 41 away, only one gave the prime number clue:
- x>48; (x-48) is prime
- x<130; (x+130)'s largest prime divisor is 73
So, yes, you can't rule anything out just because you didn't get "(x - y) is prime" clue. You can use that to lean toward one number vs. the other like with 212 vs. 253 with today's puzzle. 212 being divisible by 4 while 253 being an unhelpful 11 * 23 is a more important reason to do that, as you explained above.