I thought I had responded to your previous message, but I can't find it anywhere.
Can you explain this "Wrong. 729 - x is prime, which means that 729 + x is also prime, per my last comment"?
I'm not sure that "729 + 646 = 1375" would prompt a "x + 729's largest divisor is 11" clue. Those clues seem to usually have the divisor be fairly large...though I don't know what the limits are for fairly large.
As for 10/21, I continued my policy of only using possible solutions. After 499, I tried 499 + 7 * 35 = 744, which is divisible by 24. My return clue was "x<744; x and 744's largest divisor is 2." That means my solution isn't divisible by 3 or 4. Which means it is also 499 +n * 7 where n mod 4 = 1, and n has no prime factors above 7.
So, n is one of: 1, 9, 21, or 25. n can't be 5, because 534 is divisible by 3. Meanwhile, n can't be 13, 17, 21, 29, nor 33 because then 7 wouldn't be the largest prime divisor of x - 499. The candidates are then: 506, 562, 646, 674:
- 506 is unlikely because it might have generated "x - 499 is prime" as its first clue.
- 562 + 744 = 1306 = 2 * 653. That clue seems fine. 653 is probably too big for "fairly large."
- 646 + 744 = 1390. Were 646 the answer, I think the second clue would be "x + 744's largest divisor is 139."
- 674 + 744 = 1418 = 2 * 709. That clue seems fine.