Huh. Somehow didn't even realize there was a setting for that. After changing that and grapple range I was able to beat the game no problem. Feels a bit like I sullied the intended default style now though. As for the mouse, I physically only have about a hand's width of space to move it.. Not something I can fix right now, heh.
So glad that setting let you complete the game! I've heard that impression from a few players now, I think I'm going to add some presets and a settings randomizer option on the next update to see if that helps reduce the feeling of an "intended experience" being the default and encourage peeps to experiment with those settings.