The question is which settings would that be? I have AdBlock in my browser but that's a different window than the launcher, what setting in windows could cause this to not work?
I googled and it looks like some people experience issues when they try to open URLS in fullscreen mode. I never play in fullscreen mode, so I've never actually experienced this.
If that doesn't help then there's not much I can do , I'm afraid the issue seems to be localized to your particular device.
You can also try visiting the Ren'py discord to report this issue, as it may be something the developer of Ren'py needs to sort out (or even a known issue).