- make sure no antivirus stops it. Renpy games are stopped automatically by programs like AppCheck and Acronis cause they suspect ransomware (false positive) - then, you'll have to whitelist the game once
- make sure, it is not already running in task manager (if yes and there is no window, its a microsoft bug), kill all instances of that process and try again
- re-download the game as you accidently might corrupt it through moved/copied/deleted file in that directory
- take care of you have enough free disk + memory space left