Hello there.
I'm sorry for the inconvenience.
Itch support forwarded your mail to me. I replied, hoping they would it forward to you.
According to the renpy documentation, you have to uncompress the archive and directly double-click the app.
I'm quoting the documentation because I don't own a mac and never tried it myself. However, feedback from mac users seems to confirm that.
Let me know if it helps you!
You can contact me directly on Discord for a more instantaneous discussion.