If you are making art for profit, you will have to consider to atleast some extent what type of content a consumer would be interested in. That said, it is possible to have art made for a consumer that also has personal meaning to the artist.
As an artist, I've found there needs to be a balance between marketability and personal connection when making art. If something is purely based off of what I know will sell, I'll get bored and the art will be uninspired and dull. If it's purely based on what I want to draw with no concern for the consumer, I'll have fun making it but little luck selling it.
I would also say there is a place for dull and boring art. Dull and boring art tends to be very clear in its messaging, removing the possibility of confusion.