I just now ended up defeating the Hydrangeas by using the Nasty Weapon Coating (or whatever it was called, gives +4 to ATK for a day) and a Vitality Potion. I'm not sure if this was a worthwhile trade - I think it'd be more cost-effective to go with your idea with the bombs.
I've been uncertain of where to use Pierce since the game doesn't usually tell me how heavily armored opponents are, so I've hesitated on spending the two days to get it. I suppose it'd be useful against the demon.