From the sounds of things, no, not really? There is some difference between the state of things before and after that point, but I think it's going to have no impact on your run.
Neato, I've progressed some... oh, lovely, a new curse. Eyes of Greed... hits willpower whenever I spend money, for 2% of the amount I spend. Well shit, that's pretty devastating. This on top of the +4 corruption. I hope saving those refugees was worth it.
