If you're talking about Anomalies (to capture), homebrewing those is easy! If you mean Anomalies (Character piece) those are a little tougher. In the final game, each of the 9 Anomalies have 21 abilities total. Making a new one is a pretty big undertaking, but it's possible!
Overall, I think TA has lots of room to add stuff in, but homebrewing it with a full reskin/overhaul is going to be challenging. The mechanical design is tied pretty closely to its specific story world. I'm interested to see what people come up with, though!
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Look forward to seeing the full release. Think my players from grad school looking for something more combat focus but really love the presentation here and control vibes. Would love to take a crack and homebrew something from TA. Tried with gurps but proved to be lil too much and wasn’t getting anywhere. Think the anomalies I came up with would translate well to TA actually.