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I only had a few unlocks that I had not unlocked after playing for a very, very long while before starting to try to unlock those specifically. The Spades symbol (unlocked by having enough blue symbols in your deck) and the item making mini-games easier (play enough mini-games) were some of the unlocks that I had to do specific runs for. I also had to do a specific run to get the 100 maximum health unlock, I got it by grinding the bouncers with a deck that included the Apple symbol, life steal, and money gain, a green-yellow deck (I have a screenshot of the deck in the posts below). I do not remember what other unlocks I had to do specific runs just to unlock them.