I managed to find a build that looks like it will go the distance for any endless run.Every Shield's Forge slot is filled with the +1 Haste effect.
Each turn I gain a tonne of actions thanks to the Ore, and then each time I hit a Hercule, I gain a bunch of Block which is then converted to Damage, while also gaining a tonne of stacks of Haste, which leads to even more Block next action. If I can't defeat all enemies by the time I've used up all Actions, I'll still have enough Block to survive whatever attacks come my way, and I have the Swamp Shield to remove any Poison I suffer. And since there are no weapons in this build, I can use Pacifist's Rings too.