If it is Renpy, the normal executable should work. Renpy usually doesn't cause problems.
If it doesn't, it may be a problem with your PC's drivers.
Try to run the game normally, that is, the normal .exe. If it is not executed, the log.txt or traceback.txt file would have to be created
Take those files and consult directly in the renpy community, since it will be easier for them to tell you the problem.
https://lemmasoft.renai.us/forums/
However, from what you describe, I think it is a problem with your PC drivers.