itch.io

I would like to say gay is the way but I haven't tried hetero. There is so much gay and it is wonderful for sure. But the replayability of this game is kinda crazy so you could always try both.

TL;DR gender and sexuality don't lock you from content (excluding one scene but that is a scene only for tops so you might not care if your character is a bottom), and nothing is truly missable except for permanent choices from the nameless, and the morality choices because you can't change what happened without a reload.

Gender and sexuality don't affect the game enough to be a concern, just pick whichever one you want since the only thing it really does is change some Dialog from "penis" to "vagina" in sex and gives you female or male pronouns. 

https://docs.google.com/spreadsheets/d/1bD0wt-goZe93J-i3HIMd1AkY81NGBUa4Yi-r3LqN... this is the guide.

also only a little bit of content is missable right now, and almost all of them revolve on you being either evil or nice. also you can reload an older save to get anything you wanna know about, such as if being a dick would be fun. there is only one exclusion to that, and that one particular is the nameless and his events. so be EXTREMELY careful during the his choices. it has to be something you actually want because the nameless blocks your ability to change your choice even if you reload. 

but back on the other missable stuff that's hard to change, that is the green and red options. you can reload your save to change these but it's usually pretty far back and quite annoying to redo everything up till that point you needed to reload from. also the  choices being red and green mean it's important and your choice will either have consequences, or a reward. well depending on what you feel would a reward it might be useless for some of them. an example for green that gives a reward would be saving the lizard people instead of corrupting them, if you save them they have sorts of stuff for you, such as cleansing water which removes all debuffs/status ailments! (excluding literally nothing since I've used it to even cleanse being tired/exhausted lmao). and an example of a "bad" green choice.... only one thing comes to mind and that is a certain characters... situation. he's in a real bad spot and if you choose the red option, it technically keeps him out of the situation and saves him from his fate. that is also my only example of a "reward" for red choices, however even then it's not absolute since he may have gotten into a new situation and either left it worse, or better. so usually green is just better both morally and content wise, unless you don't mind the punishments and want the stuff locked behind the evil choices. then it's really just up to you.