Interesting idea! I played on the web, I had to zoom the page out to fit the whole thing on the screen, I know the nightmare of getting the resolution right on the web page, and I made it work, just make sure you fix it when the submission unlocks. The one eyed enemy projectile is way too fast, and the little initial virus enemy is a little too fast as well, the pop up windows spread way too fast (I like that idea though) the little virus guys spawn way too much and form a permanent shield against the larger enemies, causing the popups to exponentially appear
I like the foundation, maybe you should be able to shoot the X of the popup windows to close them as well rather than just destroying the entity that made it
Gotta add upgrades!
I know you can't change most of this until judging is over, just some feedback
Good work!