not really the type of game i was thinking but sure
my thought was a game like the current one but with the ability to open a portal
and maybe even a basic build system to allow you to build cover and walls this would help the inq ai to defend the area and restrict movement
maybe also with that building system they would call in enforcers aka girls
and tamers aka futas and girls and males
if you place down tamer cages you can slowly turn back the normal creatures from the infected ones
a tamer will breed the creatures and the lore behind the inq tamers is their trained in mental control and sexual control allowing them to tame anyone back into their normal state of mind
you could also setup icons on the map to show the amount a inq base has tamed and also show the infection on the map with a color system
this would show areas of high infection and high control from the inq
a base also would resupply their guards and units but only we can place new bases and spawn zones
the way they could get wiped out is if they get infected and their leaders become infected the leader would stand at the portal to guard it but the leader will corrupt it to the lewd empire and letting in say succubi or even a new empire you can personaly make for your universe