Main desire can be increased passively when other desires are high enough or when wearing Bunny set gear. It's also increases when an adventurer gets the "Clearheaded" or "Denied" affliction after lust damage is maxed and goes down while under the other afflictions.
Boob size is mainly changed by Cow set gear as it is integral to their class's functionality (wearing 3 pieces forces a class change so be careful.) it can also be changed in the hospital directly for free once you unlock it.
All afflictions aside from "Clearheaded" and "Denied" have a chance to force an adventurer to orgasm, this gives them a status effect that reduces speed and increases damage taken.
Submission is raised by wearing cursed gear. Its affliction disables damaging moves.
Exhibitionism is raised when armor is damaged. Its affliction forces your adventurer to strip herself or others.
Masochism is raised by taking damage. Its affliction occasionally forces taunt and guarding tokens and your adventurer's attacks will deal half damage to herself.
Libido is raised by taking Lust damage. Its affliction forces your adventurer to molest other adventurers.