Few things i noticed.
If you get the Futa shed szene, the charakter sprite of her doesnt disappear while the szene plays but doesnt double afterwards.
If you go to the potion shop and interact about the potions, while you are on on their questline, all buttons and options disappear like betweeen textboxes right before the next is displayed while only the background and character sprites are visible (I think that the game in this moment doesnt has an answer for that, that can be displayed) and it comletely stunlocks your game and you loose all unsafed progress cause you cant fix it. I dont exactly know when that happened tested it 2 or 3 times, i think one was while getting the adventurer information. (I talk about the lizard shopkeeper only like the dialogue option; Futa Potion (!) and for the other one)
There are other things that dialogue sprites in certain situations dont disappear but in that case, they disappear after sleeping. Happend 2 times, i think i clicked to fast in the library that caused one of them.
Hope that helps.
I save often so i dont run into progress lost because of things like that.