Thanks for the updated file, but still it doesn't work. This time the error message is “pdex.dylib” can’t be opened because Apple cannot check it for malicious software." and in the Simulator console "/PlaydateSDK/Disk/Games/mdma.pdx/pdex.dylib' not valid for use in process: library load disallowed by system policy)".
Viewing post in Mega Dystopia Micro Architect (MDMA) comments
It seems like this issue is occurring on the simulator/system end. Are you able to run any other games? What does it show under the "Security" section in your System Settings > Privacy & Security?
https://support.apple.com/en-gb/guide/mac-help/mchleab3a043/mac
Did you try opening the game from another location (e.g. Downloads)?