I picked starting settings of "Male only Visitors, Female only Creatures", but for some reason, events keep occasionally saying some of the visitors turn into Male Minotaurs; after some time of this, it starts having events with Male Minotaurs interacting with Male Visitors. In the current run where I'm testing this, this happened around the 7th event. After playing through until Day 2, by the end of the day there are 15 Male Minotaur and 10 Female Minotaur, despite starting with 2 Female Minotaur.
I've also tried disabling M/F under these settings, and that setting fails eventually too. After a lot longer of course, namely around the 17th event or so.
I've avoided doing Medusa's, but during the short time I took a look to see how their content goes, I didn't see any Male Medusas result; so part of me wonders if its a Minotaur specific issue.
Edit: Strangely, a Vistor turned into a Male Dragon after I added a Female Dragon. After resetting again, a Male Minotaur resulted in the first event.