I'm also having this issue, and re-extracting the file isn't helping. I can still play it, though i have to blindly click on things until i activate it.
Viewing post in RESIDENT CHEESEL: MOUSHLEY comments
Hello to all users receiving this glitch. I've uploaded a build that's no longer in debug mode, and removes a function call that I believe was causing some glitches (titled BUGFIX_WINDOWS). Please let me know if it fixes the black screen error. If it does not, could you please let me know what kind of device you are using, if you're running it through a virtual machine, and, if the glitch does not immediately happen when you run the game, what steps you took in the game before it happened (that you can remember)
I'm very sorry this issue is avoiding my attempts to replicate it. I've got a feeling it must be a device specific issue since it's affecting such a small minority of users (that have reported) and I want to fix it if we can figure out why it's happening.