It just shows a blank dark green screen for me:
Edit: This is now fixed in version 1.0.4
Weird! That means something must be throwing an exception while loading the game, but it's getting enough into the loading to start rendering the background color. I could get an idea of what went wrong if you press Win+R, paste in %USERPROFILE%\AppData\LocalLow\Nifflas' Games\Xenosphere - the last bunch of lines of Player.log will probably contain information about what happened, the info will probably begin with the word "Exception" but I'm not 100% certain
One thing that might fix it is installing the latest Visual C++ Redistributable from https://learn.microsoft.com/en-us/cpp/windows/latest-supported-vc-redist?view=ms... (the X64 version)
Here's my Player.log: xenosphere - Pastebin.com. I installed the redistributable but no joy I'm afraid
I've fixed it now and uploaded a new version: 1.0.4, which you can download on this page!
The explanation for the bug is, before I fixed it just now, my adaptive music software opened instruments with read/write access instead of just read access, which means the OS denies access since the "Program Files" directory is protected. Most people probably ran it from the desktop or download folder, which is why they weren't affected.
Thank you so much for giving me this log data! This has been helpful in a very big way, especially since this is a mistake in code I use in multiple projects.