The amount of work gone into this is very impressive, and the game can definitely eat up a few hours even at this stage.
But for my own personal ability to satisfy my ethics and enjoy the game, I'd appreciate if you could clear some things up for me (and maybe add the answers to the game in a throwaway line somewhere?): Is Jen bisexual, and would Karen be okay with Jen fucking other people (and especially men)? I'm hoping the canon answers to these questions are yes, because I don't want to be forcing Jen to have sex she doesn't enjoy, and I don't want to have her cheating on her girlfriend.
I'm also not sure how I feel about the scene at the beginning where Karen is, frankly, being raped. I understand it's there to help the player understand that something more is going on with the villain's abilities, but honestly I'm not sure how well it does that.
I think the same or better effect could come across with the villain approaching Karen in a cell and asking her questions while she gets eaten out by someone she's in full control of already, as an intimidation tactic, but Karen is never involved. It still gets the message across that the villain can control people, and explains what has happened to Karen, but doesn't involve her getting raped, and I would prefer that to what is currently in the game.