I'll answer the second one, You have to complete ANY level of your choice using 4 of the following: Lil Chad, Cube of Meat, Spike Baby, Tooth n Nail, Lil Loki or Double Baby.
anthropomorphine
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Alright by far Challenge #5 is the hardest one of them, but I feel that this isn't a skilled based one, so far everytime I have died it's all been caused by one enemy: Flies. I think they are simply too fast for the first shot of a wiz/Loki to catch up with them, they only start dying when the baby is already shooting at something else on another tile, of course this is just a problem on the spiked filled lanes, middle two flies just die when they touch a tower. When one of them reaches the end, you're gonna be praying that one of the lokies' backshots hits them or else you're doomed the next second.
Is it possible to remove them entirely, or at least tone down on the amount that comes from the sides? I think asking to change how fast babies shoot and how they detect enemies might be a tad too much right now, so I'll leave that out of my suggestions for a fix of this challenge.
At the game over screen, by clicking a bunch of times you can replay the animation of Isaac getting kicked, it may be a feature? I'm not sure, since when you do this, the text under the big game over letters is different everytime, which I had never seen before, I always got the phrase "It's not your fault.." whenever I died.
(Call me a conspiracy theorist but there may be an Easter egg here?)
I'll echo the sentiment of the other fellas and say that the game is absolutely harmless, I think that because it's just a raw .exe file, your computer is automatically built to block it or warn you about it, somebody mentioned this in bugs but changing the download to a zip file could fix this problem and would stop people from getting icky about it.
I'd suggest that for the boss levels, make the babies spawn a bit quicker? (At least the blue room - mines area) Because an enemy could slip by pretty easily and you wouldn't have anything on hand to stop it, id say all the (first loop) regular levels were pretty good to control but when it came to the first wave of the bosses, that part nearly killed the run everytime.
(Btw the concept of this game is genius, so just props to you for creating this, it's amazing)