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Another big idea would be a new type of ammo and weapons: poison.

Capacity 55 (75 with back muscle)

Related mutation: toxic tears, enemmies killed with poison weapons ( including the ones that dont use poison ammo) explode into a big toxic cloud

Some weapons:

- bug spray: 1 ammo, shoots 3 small toxic clouds that lasts for 3 sec, similar to a shotgun 

- spitter: 1 ammo shoots a toxic bubble that deals 7 damage, when it hits something it leaves a small toxic cloud

- flautulent gun: 3 ammo shoots a big toxic cloud that leaves a trail of small toxic clouds

Sry for my bad english and if you didnt understand something tell me

New crowns:

-crown of gifts: replaces the normal ammo chests with 2 present ammo chests (synergy with open mind)

-crown of bounty:  gives 1 extra mutation but at the start of each level the idpd will appear

edit:

extra:- crown of cuteness: takes the slot for crowns and pets, enemmies will attack slower(reduces enemy fire rate)

sry for my bad english