If anyone wants advice on a fight or a strat, I can probably help. I'm 20-3 on my runs and have had all sorts of builds, with screenshots of all of them after the final boss.
Fun cauldron+Regen build when I got a Red Hoodie from Matthew. 121 hp at the end with double seasoning healing for 30 hp base consumables and I think 60 for the 10hp drinks.
I used Matthew to start the game with a rare item as a challenge run (keep it no matter what) and got this item. Ended the run with over 120 hp. Not even sure if I used the healer to increase max hp or not. Cauldron+Seasoning for regen and ninja armor for defense otherwise.
That's what that bug is? I've had it generate 2 gems for me several times in a row. I thought it was a bug with endless mode since it happened on the 10th floor, but it must've just been the enemies health lining up nice with my damage.
If you can't find anything else, seasoning is a pretty good counter to poison. But mostly you need to be able to 2 turn kill snakes by the time you have to fight 2 at once. That's 40 damage per turn, which should be achievable.
