Petite coquille dans le chapitre 2, en anglais uniquement :
« It's a dish from Alsace, a northwestern region of France »
Yes, on linux at least (so most likely also on mac), the itch.io app uses a security wrapper to isolate executed programs (called firejail). It runs applications into a sandbox to avoid giving access to more data than necessary.
To run the VN, one has to remove the exclamation mark from the folder name, the 'EverythingChanges!.sh' and 'lib/py3-linux-x86_64/EverythingChanges!' files.
The bug was already reported to itch.io but their client didn't get any update since 2021.
The game can't be updated automatically because the platforms are not set for each file. That's something the developers have to do for each new version.
the platforms for the *-pc.zip file are windows and linux, android for the apk file and apple for the -mac.zip file.
Meanwhile, to transfer your saves from the old to the new version, you can copy the game\saves folder into the new version folder.