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I'm on windows 10, godot 3.4.2. 

I'm not familiar with the C# version of godot to understand how to troubleshoot what you suggest. I must be missing steps for general use. Clicking Build also results in error, "Failed to build project solution." Before trying this plugin I have never used anything but the standard gdscript godot.

I realize this is now an old thread, but I get the same issue:

Unable to load addon script from path: 'res://addons/TwistedIK2/TwistedIK_PluginRoot.cs'. This might be due to a code error in that script. Disabling the addon at 'res://addons/TwistedIK2/plugin.cfg' to prevent further errors.