yes I got it working with whisky (a wine wrapper with macOS own take on proton) and it does work somewhat ok but it's nowhere as fast as on an old PC. :) would be amazing the game get reverse engineered so we have native version for other OS. Like arm Linux too.
it works decently on macos with parallels but then this thing takes like 40GB of storage.. that is way too much just for noita... I hope you can make a build for macos, even just x64