Sleeping at the inn should be streamlined. Right now there are so many steps you have to go through just to advance a day, even just to simply pay for a room.
You have to talk to the inn-keeper, go through all the dialogue, walk upstairs, load, walk into the room, load, walk to the furthest corner of that room, wait for your character to undress, then you rest, load, wait for character to dress again, and you're FINALLY done. There should just be an option to pay 10 silver and just advance to the next day while recovering your HP, fade out, fade in, done.
Same deal with working for the inn-keeper, do you really have to do the same task over and over, read the same dialogue again and again? There's two important parts, the sex scene, and getting your room. After the first time, you get the idea, there should be an option to just skip all the fluff and get to what you want: sleepin' or fuckin'.
Speaking of unnecessary wastes of time, how about an item that lets you teleport to the waypoints, instead of having to walk to them? Oh yeah, and walking, it should be set to "run" by default. Ain't nobody ever gonna go around at the basic walking speed without holding down shift, so why even have that there at all.
Left-clicking with the mouse should go through dialogue.
There should be more stash locations in high-traffic areas, like next to waypoints. Right now a lot of them are in plain inconvenient places that you often have to go through dialogue just to open your stash, like at Nora's house (if she's in your party) or in the inn's rooms.
When you're out of actions with a character during combat, your turn should just automatically end. Why waste time making players do it manually? On that note, if you still have actions left there should be an additional confirmation step in case you accidentally hit the quit turn button.
Inventory management is a pain. If one character's inventory is full, and the other has space, looting should just send the items to wherever there's room for them instead of making you switch to the other character manually. These are all small issues, sure, but when you add it all up it makes the game much more tedious than it should be because you constantly have to hold its hand to make it do things that should be automatic.