I've used most of these, some I haven't but going off their ability (not taking into account of the cooldown of said item) I put them where they are. I wanna see others opinions through discussion or maybe even their own tier lists too!
The Binding of Isaac fangame, heavily inspired by Plants vs. Zombies · By
In my opinion I think that red candle can be better on stages with stoners because if they pull all the enemies on the other lanes for example gapers, plums, and hardheads, then you would use red candle to kill everything on that lane, also hitting a columm can be helpful but is more situation in my opinion so I would put red candle in s with blue candle.