I have some struggles with the emote switching while beeing ingame.
If i tab out, everything is fine and the emote switching works perfectly.

but ingame it does nothing. i assume it has to do with the game engine? (valorant for example)
i tired Alt + X key assignments and FX key assignments. but neither works somehow even tried Pos1 and END key

someone got any kind of tips to me?

If a game is overriding the use of any of the hotkeys, or any other program you're using for that matter, it won't work.