When I play the game it seems like there are literally no downsides to running except tripping on something which is off by default and food/sleep also doesn't decrease faster so I just run everywhere which is kinda boring.
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Same as real life, assuming you weren't out of shape. Can just run everywhere. Only downside is needing to eat or drink more because you're doing physical activity.
Most realistic part of the game. You too could be this powerful. Get your running shoes on and hit that pavement bro, get fit bro. Become speed.