There are 2 ways to get Josef out of the House:

• Make him cheat on Anna by having a threesome with Isabella on Thursday
• Call him a loser when you're talking to him at the Entrance of the House on Friday

As for Adrian, he will not exactly be leaving the House like Josef does. But it is necessary to pick Adrian Leaving Route in order to unlock certain Endings.

In order to do that, here's what you have to do:

• Progress with the Main Storyline and go Upstairs to catch Josef and Adrian arguing about trip to Japan
• Then go to Adrian's Room and talk to him to trigger the dialogues indicating Adrian Leaving or Stays in the House
• Pick the Adrian Leaving Route and he'll ask you for some money to go to Japan by himself
• Progress with the Main Storyline further in order to get the money and give it to Adrian