What operative system are you running on and are you using an antivirus that might be interfering with the game?
Your issue mostly sounds like this open NWJS issue. It means that either your AppData directory has modified permissions so that NWJS can't access it, or that another instance of NWJS is running. If it's the first, try running Game.exe as administrator. If that doesn't work, try restarting your computer (I've had issues with invisible NWJS instances in background before...)
If none of that works, you can try starting Game.exe by opening the Command Prompt/PowerShell in the directory with Game.exe and then running the "Game.exe --disable-gpu" command. No guarantee that any of this works, but it might be worth a try.
