New & popular Card Gamewith Mouse support (1,868 results)
Explore Card Game games with Mouse support on itch.io. Featuring gameplay centered around the strategic use of cards, these games often involve building decks, managing resour · Upload your games with Mouse support to itch.io to have them show up here.
New itch.io is now on YouTube!
Subscribe for game recommendations, clips, and more
Someone sits in your office with dark questions. Discover ancient mysteries, but choose your answers wisely.
Adventure
Card Game
A tower defense focused on card combos, mechanical synergies, and a limited tower count
Strategy
timetravelling deckbuilding boss-rush game made for Boss Rush Jam 2025
Card Game
Play in browser
Play as a mimic out to woo an adventurer with her shapeshifting abilities
Card Game
Play in browser
Quick card game. Be a General, organize your units, maximize your points, minimize your losses, and win the war!
Card Game
Play in browser
How long can you last when time is your enemy, and your enemy's friend?
Card Game
Play in browser
A fast-paced, physics-driven sword combat game with randomized enemy weak spots and escalating waves.
Action
Play in browser
Face-off with your opponents in an epic battle of might and magic with game pieces and spells.
Card Game
Play in browser
Loading more games...