Triple agree, I built Gauntlet 2D for the first time yesterday, night before I uploaded on to itch! The biggest issue I had was UI scaling, what a pain that was. It was way off in the WebGL build. I had to finagle it to look alright super late at night. It was part of the reason I finished uploading it this morning and not last night.
Even now I had to put a disclaimer on top of my itch page saying "Play full screen for best experience". I bet if I would have done some builds earlier in development i would have caught those issues.