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I couldn't figure out how to lock on to the boss. I can TAB to lock on enemies, but on on the boss. Am I missing something or was that on purpose?

It wasn't on purpose and it's working for me just fine. I just ran through the game once more and the only problem I got was my cursor didn't locked to the game client, so I lost focus from the game and my inputs wouldn't work. The most noticeable clue here is you won't hear any sound from the game once the focus lost.