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I can't remember all the details, but it was on the second stage.  I had a power up guy with me, and maybe I had just cleared a wave?  The interesting thing was, all the sprites disappeared on the screen, but the audio cue for the laser firing was still completely responsive.  I tried hitting a few buttons and waiting it out a bit, but nothing changed.

huh that's really weird. I'll do some more testing to see if I can reproduce it. Thanks for sharing!