I asked the support team and got an answer.
The chance that the limits will be increased is rather small. You have to explain exactly why the game has to be played in the browser and why a download makes no sense.
Since I have developed my game especially for browsers (no game engine export) and it primarily runs on my own website, I will probably rely on additional pwa elements and use a wrapper for a download version.
I have combined graphics of the same size into sheets and reduced the number of files to about 500. All in all, I think Itch is the wrong place for complex browser games.