Do you see any error messages or anything? What specifically happens when you try to launch it? Have you tried to run it from the Itch Desktop Client? Do both the original jam build and the post-submission camera sensitivity settings build both have the issue?
Unfortunately, I'm still on High Sierra on my 2012 Macbook Pro, and my wife's 2010 iMac is still on Sierra. Both old macs run the game fine though.