Theoretically - it would be cool. Practically - too much work. It's strange to spend time on implementing hardcore survival mechanics when you have untouched regions on map without quest and encounters.
Realistically - I see this feature in following way - when you damage body part 3 times (3 stacks) you will receive permanent wound, that will give additional de-buffs and it could be healed only in Elise clinics.
Game already have similar mechanics with creampie: when you get 3 stacks of creampie you'll get cumflation, that will decrease SPD even more.